Integrating advanced analytical methods to assess epigenetic marks affecting response to hypomethylating agents in higher risk myelodysplastic syndrome

Integrating advanced analytical methods to assess epigenetic marks affecting response to hypomethylating agents in higher risk myelodysplastic syndrome

Abstract Background Patients with higher-risk (HR) myelodysplastic syndrome (MDS), ineligible for allogeneic hematopoietic stem cell transplantation (alloHSCT), require prompt therapeutic interventions, such as treatment with hypomethylating agents (HMAs) to restore normal DNA methylation patterns,...

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Main Authors: Theodoros Nikolopoulos, Eleftherios Bochalis, Theodora Chatzilygeroudi, Vasiliki Chondrou, Irene Dereki, Katerina Athanasopoulou, John Zafeiropoulos, Kyriakos Bourikas, George P. Patrinos, Argiris Symeonidis, Argyro Sgourou
Format: Article
Language:English
Published: BMC 2025-02-01
Series:Molecular Medicine
Subjects:
Myelodysplastic syndromes
Hypomethylating agents
Response assessment
DNA methylation
LC-MS/MS analysis
MeD-seq data analysis
Online Access:https://doi.org/10.1186/s10020-025-01123-7
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https://doi.org/10.1186/s10020-025-01123-7

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