Progression of Diabetic Retinopathy and Declining Renal Function in Patients with Type 2 Diabetes
Background. At a university hospital in Korea, we conducted a retrospective study to determine the association of the progression of diabetic retinopathy (DR) with declining renal function in type 2 diabetes. Methods. We included a total of 1527 patients with type 2 diabetes who followed up in our d...
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| Format: | Article |
| Language: | English |
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Wiley
2020-01-01
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| Series: | Journal of Diabetes Research |
| Online Access: | http://dx.doi.org/10.1155/2020/8784139 |
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| author | AJin Cho Hayne Cho Park Young-Ki Lee Young Joo Shin So Hyun Bae Hakyoung Kim |
| author_facet | AJin Cho Hayne Cho Park Young-Ki Lee Young Joo Shin So Hyun Bae Hakyoung Kim |
| author_sort | AJin Cho |
| collection | DOAJ |
| description | Background. At a university hospital in Korea, we conducted a retrospective study to determine the association of the progression of diabetic retinopathy (DR) with declining renal function in type 2 diabetes. Methods. We included a total of 1527 patients with type 2 diabetes who followed up in our diabetes clinic and underwent fundus photographic examinations from August 2006 to February 2014. DR was assessed by retinal ophthalmologists using comprehensive ophthalmologic examinations. Results. The baseline prevalence of nonproliferative DR (NPDR) and proliferative DR (PDR) was 26.5% and 14.7%, respectively. Among 1303 patients with no DR and NPDR, 134 (10.3%) patients progressed to NPDR or PDR. The progression group had longer duration of diabetes, higher fasting plasma glucose, higher HbA1c, and a higher rate of ≥20% decline in eGFR during the follow-up period. After multivariate analysis, ≥20% decline in eGFR (odds ratio 2.553, 95% CI 1.219-5.348, p=0.013) was an independent risk factor for progression of DR in patients with NPDR. Conclusion. Declining renal function was independently associated with DR progression in patients with NPDR, suggesting that investigation of DR status should be recommended for patients with declining renal function. |
| format | Article |
| id | doaj-art-93fb2134b26a4adea79ec736c623830b |
| institution | Kabale University |
| issn | 2314-6745 2314-6753 |
| language | English |
| publishDate | 2020-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of Diabetes Research |
| spelling | doaj-art-93fb2134b26a4adea79ec736c623830b2025-02-03T06:46:38ZengWileyJournal of Diabetes Research2314-67452314-67532020-01-01202010.1155/2020/87841398784139Progression of Diabetic Retinopathy and Declining Renal Function in Patients with Type 2 DiabetesAJin Cho0Hayne Cho Park1Young-Ki Lee2Young Joo Shin3So Hyun Bae4Hakyoung Kim5Department of Internal Medicine, Kangnam Sacred Heart Hospital, Seoul, Republic of KoreaDepartment of Internal Medicine, Kangnam Sacred Heart Hospital, Seoul, Republic of KoreaDepartment of Internal Medicine, Kangnam Sacred Heart Hospital, Seoul, Republic of KoreaDepartment of Ophthalmology, Kangnam Sacred Heart Hospital, Seoul, Republic of KoreaDepartment of Ophthalmology, Kangnam Sacred Heart Hospital, Seoul, Republic of KoreaDepartment of Ophthalmology, Kangnam Sacred Heart Hospital, Seoul, Republic of KoreaBackground. At a university hospital in Korea, we conducted a retrospective study to determine the association of the progression of diabetic retinopathy (DR) with declining renal function in type 2 diabetes. Methods. We included a total of 1527 patients with type 2 diabetes who followed up in our diabetes clinic and underwent fundus photographic examinations from August 2006 to February 2014. DR was assessed by retinal ophthalmologists using comprehensive ophthalmologic examinations. Results. The baseline prevalence of nonproliferative DR (NPDR) and proliferative DR (PDR) was 26.5% and 14.7%, respectively. Among 1303 patients with no DR and NPDR, 134 (10.3%) patients progressed to NPDR or PDR. The progression group had longer duration of diabetes, higher fasting plasma glucose, higher HbA1c, and a higher rate of ≥20% decline in eGFR during the follow-up period. After multivariate analysis, ≥20% decline in eGFR (odds ratio 2.553, 95% CI 1.219-5.348, p=0.013) was an independent risk factor for progression of DR in patients with NPDR. Conclusion. Declining renal function was independently associated with DR progression in patients with NPDR, suggesting that investigation of DR status should be recommended for patients with declining renal function.http://dx.doi.org/10.1155/2020/8784139 |
| spellingShingle | AJin Cho Hayne Cho Park Young-Ki Lee Young Joo Shin So Hyun Bae Hakyoung Kim Progression of Diabetic Retinopathy and Declining Renal Function in Patients with Type 2 Diabetes Journal of Diabetes Research |
| title | Progression of Diabetic Retinopathy and Declining Renal Function in Patients with Type 2 Diabetes |
| title_full | Progression of Diabetic Retinopathy and Declining Renal Function in Patients with Type 2 Diabetes |
| title_fullStr | Progression of Diabetic Retinopathy and Declining Renal Function in Patients with Type 2 Diabetes |
| title_full_unstemmed | Progression of Diabetic Retinopathy and Declining Renal Function in Patients with Type 2 Diabetes |
| title_short | Progression of Diabetic Retinopathy and Declining Renal Function in Patients with Type 2 Diabetes |
| title_sort | progression of diabetic retinopathy and declining renal function in patients with type 2 diabetes |
| url | http://dx.doi.org/10.1155/2020/8784139 |
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