Overexpression of Nrf2 in bone marrow mesenchymal stem cells promotes B-cell acute lymphoblastic leukemia cells invasion and extramedullary organ infiltration through stimulation of the SDF-1/CXCR4 axis

Overexpression of Nrf2 in bone marrow mesenchymal stem cells promotes B-cell acute lymphoblastic leukemia cells invasion and extramedullary organ infiltration through stimulation of the SDF-1/CXCR4 axis

BackgroundTumor microenvironment (TME) represents the key factor inducing leukemia development. As stromal cells within the leukemia microenvironment, Bone Marrow Mesenchymal Stem Cells (BM-MSCs) can trigger leukemia progression under certain conditions. As a critical transcription factor, nuclear f...

Full description

Saved in:
Bibliographic Details
Main Authors: Lin Zheng, Chengyun Pan, Dan Ma, Qin Shang, Tianzhen Hu, Tianzhuo Zhang, Qian Kang, Xiuying Hu, Shuyun Cao, Li Wang, Hong Luo, Jishi Wang
Format: Article
Language:English
Published: Frontiers Media S.A. 2024-07-01
Series:Frontiers in Pharmacology
Subjects:
B-acute lymphocytic leukemia
MSCs
Nrf2
SDF-1/CXCR4
extramedullary infiltration
Online Access:https://www.frontiersin.org/articles/10.3389/fphar.2024.1393482/full
Tags: Add Tag
No Tags, Be the first to tag this record!

Internet

https://www.frontiersin.org/articles/10.3389/fphar.2024.1393482/full

Similar Items