SC134-deruxtecan, a fucosyl-GM1 targeting ADC for small cell lung cancer therapy

SC134-deruxtecan, a fucosyl-GM1 targeting ADC for small cell lung cancer therapy

Abstract Background Small cell lung cancer (SCLC) remains a difficult disease to treat with poor long-term survival rates. New therapies offer modest overall survival benefit beyond that of chemotherapy alone, necessitating the development of improved therapies. Fucosyl-GM1 (FucGM1) is a glycolipid...

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Main Authors: Bryony Heath, Bubacarr G. Kaira, Dhruma Thakker, Omar J. Mohammed, Ruhul Choudhury, Foram Dave, Poonam Vaghela, Elena Dubinina, Tina Parsons, Lindy Durrant, Mireille Vankemmelbeke
Format: Article
Language:English
Published: BMC 2025-08-01
Series:Journal of Translational Medicine
Subjects:
Fucosyl-GM1
Glycolipid
Internalization
ADC
Small cell lung cancer
Online Access:https://doi.org/10.1186/s12967-025-06940-2
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https://doi.org/10.1186/s12967-025-06940-2

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