The MFGE8/integrin β3 axis mitigates experimental neutrophilic asthma by suppressing NLRP3-Caspase-1 pathway-mediated NETosis

The MFGE8/integrin β3 axis mitigates experimental neutrophilic asthma by suppressing NLRP3-Caspase-1 pathway-mediated NETosis

Abstract Background Neutrophilic asthma, characterized by the relative accumulation of neutrophils in the airways, constitutes a distinct endotype of asthma resistant to corticosteroid and associated with severe and uncontrolled cases. Milk fat globule-EGF factor 8 (MFGE8) is a soluble glycoprotein...

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Bibliographic Details
Main Authors: Shanshan Wang, Tang Kun, Zhen Tian, Mengqi Huang, Yan Fan, Boyu Li, Hongyan Zheng, Rongman Xu, Meijia Wang, Jianping Zhao, Jungang Xie
Format: Article
Language:English
Published: BMC 2025-07-01
Series:Respiratory Research
Subjects:
Neutrophilic asthma
MFGE8
Integrin β3
NETosis
NLRP3
Online Access:https://doi.org/10.1186/s12931-025-03313-7
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https://doi.org/10.1186/s12931-025-03313-7

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