Proteomic characterization of the pseudocapsule of clear cell renal cell carcinoma in VHL disease reveals a distinct microenvironment at the tumor boundary zone

Proteomic characterization of the pseudocapsule of clear cell renal cell carcinoma in VHL disease reveals a distinct microenvironment at the tumor boundary zone

Von Hippel-Lindau (VHL) disease describes a hereditary tumor predisposition syndrome, caused by germline mutations in the VHL tumor suppressor gene, resulting in the functional loss of the VHL protein (pVHL). pVHL loss translates into a pseudo-hypoxic state that drives clear cell renal cell carcinom...

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Bibliographic Details
Main Authors: Tobias Feilen, Manuel Rogg, Grigor Andreev, Niko Pinter, Maximilian Wess, Anna L. Kössinger, Nastasja Diel, Elke Neumann-Haefelin, Athina Ganner, Markus Grabbert, Christoph Schell, Oliver Schilling
Format: Article
Language:English
Published: Elsevier 2025-10-01
Series:Neoplasia: An International Journal for Oncology Research
Subjects:
Clear cell renal cell carcinoma
Von Hippel-Lindau disease
Pseudocapsule
Extracellular matrix
Proteomics
Online Access:http://www.sciencedirect.com/science/article/pii/S1476558625000934
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http://www.sciencedirect.com/science/article/pii/S1476558625000934

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