Mechanical Stress Induced NOX2 Promotes Endothelial Dysfunction in Ventilator‐Induced Lung Injury: Potential Treatment with Quercetin

Mechanical Stress Induced NOX2 Promotes Endothelial Dysfunction in Ventilator‐Induced Lung Injury: Potential Treatment with Quercetin

Abstract Mechanical ventilation (MV) is a treatment that helps people who are unable to breathe on their own. However, the use of MV leads to the development of ventilator‐induced lung injury (VILI). Here, it is found that VILI with endothelial barrier disruption is accompanied by elevated reactive...

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Bibliographic Details
Main Authors: Tao Jiang, Yabing Zhang, Zhiye Guo, He Ren, Weiyi Hu, Qingping Yao, Yunlong Huo, Yingxin Qi, Kai Huang
Format: Article
Language:English
Published: Wiley 2025-07-01
Series:Advanced Science
Subjects:
endothelial barrier dysfunction
endothelial cells (ECs)
mechanical stress
mechanotransduction
NADPH oxidase (NOX)
quercetin
Online Access:https://doi.org/10.1002/advs.202502639
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https://doi.org/10.1002/advs.202502639

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