A correlation of ineffective erythropoiesis and dysregulated signaling pathways in myelodysplastic syndromes/neoplasms

A correlation of ineffective erythropoiesis and dysregulated signaling pathways in myelodysplastic syndromes/neoplasms

Abstract Over 90% of patients with myelodysplastic syndromes/neoplasms (MDS) exhibit anemia at diagnosis, primarily due to ineffective erythropoiesis. This is characterized by abnormal proliferation and differentiation of erythroid cells influenced by signaling pathways including heme synthesis, fer...

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Main Authors: Junying Wu, Jinqin Liu, Jia Chen, Lin Yang, Fuhui Li, Tiejun Qin, Zefeng Xu, Jing Liu, Jiaxi Zhou, Lihong Shi, Bing Li, Zhijian Xiao
Format: Article
Language:English
Published: BMC 2025-05-01
Series:Experimental Hematology & Oncology
Subjects:
Myelodysplastic syndrome/neoplasms
Ineffective erythropoiesis
Signaling pathway changes
Ferroptosis
Online Access:https://doi.org/10.1186/s40164-025-00664-1
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https://doi.org/10.1186/s40164-025-00664-1

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