Tempol, an intracellular antioxidant, inhibits tissue factor expression, attenuates dendritic cell function, and is partially protective in a murine model of cerebral malaria.

Tempol, an intracellular antioxidant, inhibits tissue factor expression, attenuates dendritic cell function, and is partially protective in a murine model of cerebral malaria.

<h4>Background</h4>The role of intracellular radical oxygen species (ROS) in pathogenesis of cerebral malaria (CM) remains incompletely understood.<h4>Methods and findings</h4>We undertook testing Tempol--a superoxide dismutase (SOD) mimetic and pleiotropic intracellular anti...

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Main Authors: Ivo M B Francischetti, Emile Gordon, Bruna Bizzarro, Nidhi Gera, Bruno B Andrade, Fabiano Oliveira, Dongying Ma, Teresa C F Assumpção, José M C Ribeiro, Mirna Pena, Chen-Feng Qi, Ababacar Diouf, Samuel E Moretz, Carole A Long, Hans C Ackerman, Susan K Pierce, Anderson Sá-Nunes, Michael Waisberg
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2014-01-01
Series:PLoS ONE
Online Access:https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0087140&type=printable
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https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0087140&type=printable

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