LncRNA XIST promoted the stability of TLR9 mRNA in a FUS-dependent manner to facilitate aerobic glycolysis and proliferation in Th17/CD4+T cells

LncRNA XIST promoted the stability of TLR9 mRNA in a FUS-dependent manner to facilitate aerobic glycolysis and proliferation in Th17/CD4+T cells

ObjectiveTo explore the expression and function of lncRNA XIST in Th17 cells in IgA nephropathy （IgAN） and examine the regulation of lncRNA XIST on TLR9 mRNA expression.MethodsCD4+T cells were isolated from peripheral blood mononuclear cells （PBMCs） and induced to differentiate into Th17 cells.XIST...

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Bibliographic Details
Main Authors: Wu Yan-ping, Ma Xiao, Han Si-ping, Wang Xiao-qin
Format: Article
Language:zho
Published: Editorial Department of Journal of Clinical Nephrology 2022-05-01
Series:Linchuang shenzangbing zazhi
Subjects:
Th17 cells
Proliferation
lncRNA XIST
RNA binding protein
Glomerulonephritis，IgA
Online Access:http://www.lcszb.com/thesisDetails#10.3969/j.issn.1671-2390.2022.05.008
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http://www.lcszb.com/thesisDetails#10.3969/j.issn.1671-2390.2022.05.008

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