Downregulation of rRNA synthesis by BCL-2 induces chemoresistance in diffuse large B cell lymphoma

Downregulation of rRNA synthesis by BCL-2 induces chemoresistance in diffuse large B cell lymphoma

Summary: Overexpression of the antiapoptotic oncogene BCL-2 predicts poor prognosis in diffuse large B cell lymphoma (DLBCL) treated with anthracycline-based chemoimmunotherapy. Anthracyclines exert antitumor effects by multiple mechanisms including inhibition of ribosome biogenesis (RiBi) through r...

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Main Authors: Alessandra Rossi, Saveria Mazzara, Dorotea Salemi, Simone Zanetti, Maria Rosaria Sapienza, Stefania Orecchioni, Giovanna Talarico, Paolo Falvo, Alessandro Davini, Claudio Ceccarelli, Giovanna Motta, Federica Melle, Valentina Tabanelli, Claudio Agostinelli, Davide Trerè, Marianna Penzo, Chiara Corsini, Elena Baiardi, Angelica Calleri, Umberto Vitolo, Francesco Bertolini, Pier Luigi Zinzani, Roberto Chiarle, Corrado Tarella, Stefano Pileri, Enrico Derenzini
Format: Article
Language:English
Published: Elsevier 2025-05-01
Series:iScience
Subjects:
Cell biology
Cancer
Online Access:http://www.sciencedirect.com/science/article/pii/S2589004225005942
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http://www.sciencedirect.com/science/article/pii/S2589004225005942

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