Melody: meta-analysis of microbiome association studies for discovering generalizable microbial signatures

Abstract Standard protocols for meta-analysis of association studies are inadequate for microbiome data due to their complex compositional structure, leading to inaccurate and unstable microbial signature selection. To address this issue, we introduce Melody, a framework that generates, harmonizes,...

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Bibliographic Details
Main Authors: Zhoujingpeng Wei, Guanhua Chen, Zheng-Zheng Tang
Format: Article
Language:English
Published: BMC 2025-08-01
Series:Genome Biology
Subjects:
Online Access:https://doi.org/10.1186/s13059-025-03721-4
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