Human β-Defensin 3 [corrected] Exacerbates MDA5 but Suppresses TLR3 Responses to the Viral Molecular Pattern Mimic Polyinosinic:Polycytidylic Acid.

Human β-Defensin 3 [corrected] Exacerbates MDA5 but Suppresses TLR3 Responses to the Viral Molecular Pattern Mimic Polyinosinic:Polycytidylic Acid.

Human β-defensin 3 (hBD3) is a cationic host defence peptide and is part of the innate immune response. HBD3 is present on a highly copy number variable block of six β-defensin genes, and increased copy number is associated with the autoimmune disease psoriasis. It is not known how this increase inf...

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Bibliographic Details
Main Authors: Fiona Semple, Heather MacPherson, Sheila Webb, Fiona Kilanowski, Laura Lettice, Sarah L McGlasson, Ann P Wheeler, Valerie Chen, Glenn L Millhauser, Lauren Melrose, Donald J Davidson, Julia R Dorin
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2015-12-01
Series:PLoS Genetics
Online Access:https://journals.plos.org/plosgenetics/article/file?id=10.1371/journal.pgen.1005673&type=printable
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https://journals.plos.org/plosgenetics/article/file?id=10.1371/journal.pgen.1005673&type=printable

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