CD8+ T cells promote tubule-interstitial damage in malaria-induced acute kidney injury

CD8+ T cells promote tubule-interstitial damage in malaria-induced acute kidney injury

IntroductionMalaria acute kidney injury (MAKI) is associated with severe malaria and correlates with poor prognosis and death of patients infected with Plasmodium falciparum. The pathogenesis of MAKI is not completely understood but some hypotheses are well recognized. Host–parasite interactions lea...

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Main Authors: Douglas Esteves Teixeira, Sarah Aparecida dos Santos Alves, Alessandro Sá Pinheiro, Leandro Souza Silva, Rodrigo Pacheco Silva-Aguiar, Diogo Barros Peruchetti, Tatiana Almeida Pádua, Mariana Conceição Souza, Celso Caruso-Neves, Ana Acacia Sá Pinheiro
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-06-01
Series:Frontiers in Cellular and Infection Microbiology
Subjects:
malaria
tubule-interstitial injury
acute kidney injury
Plasmodium
CD8+ T cells
host defense
Online Access:https://www.frontiersin.org/articles/10.3389/fcimb.2025.1561806/full
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https://www.frontiersin.org/articles/10.3389/fcimb.2025.1561806/full

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