Chloroquine induces eryptosis in P. falciparum-infected red blood cells and the release of extracellular vesicles with a unique protein profile

Chloroquine induces eryptosis in P. falciparum-infected red blood cells and the release of extracellular vesicles with a unique protein profile

IntroductionMalaria is a vector-borne parasitic disease that affects millions worldwide. To achieve the objective set by the World Health Organization of reducing malaria cases by 2030, antimalarial drugs with novel modes of action are required. Previously, a novel mechanism of action of chloroquine...

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Main Authors: Claudia Carrera-Bravo, Tianchi Zhou, Trang Chu, Jing Wen Hang, Harshvardhan Modh, Chenyuan Huang, Sitong Zhang, Haining Hao, María José Cabada-García, Benoit Malleret, Matthias G. Wacker, Jiong-Wei Wang, Laurent Rénia, Kevin S. W. Tan
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-05-01
Series:Frontiers in Cellular and Infection Microbiology
Subjects:
eryptosis
Plasmodium falciparum
chloroquine
extracellular vesicles
proteomics
host-parasite interaction
Online Access:https://www.frontiersin.org/articles/10.3389/fcimb.2025.1553123/full
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https://www.frontiersin.org/articles/10.3389/fcimb.2025.1553123/full

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