Air pollutants and adverse pregnancy outcomes: A multi-method integration of Mendelian randomization, meta-analysis, and animal models

Air pollutants and adverse pregnancy outcomes: A multi-method integration of Mendelian randomization, meta-analysis, and animal models

Background: Exposure to air pollutants is associated with adverse pregnancy outcomes, but establishing a causal relationship remains challenging. Methods: We integrated Mendelian randomization (MR) and animal experiments to investigate causality. MR analyses leveraged data from FinnGen consortium an...

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Main Authors: Wenhan Zhou, Jiejie Shao, Juanjuan Huang, Jianfeng Gan, Yinan Wang, Jianmin Chen, Yunqian Chen, Yang Zi, Qixin Xu, Qiongjie Zhou, Huanqiang Zhao, Xiaotian Li
Format: Article
Language:English
Published: Elsevier 2025-09-01
Series:Ecotoxicology and Environmental Safety
Subjects:
Air pollutants
Adverse pregnancy outcomes
Immune cells
Mendelian randomization
PM2.5
Preeclampsia
Online Access:http://www.sciencedirect.com/science/article/pii/S0147651325010449
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