Exploring the effect of SGLT2 inhibitors on the risk of primary open-angle glaucoma using Mendelian randomization analysis

Exploring the effect of SGLT2 inhibitors on the risk of primary open-angle glaucoma using Mendelian randomization analysis

Abstract This study aimed to evaluate the causal effect of sodium-glucose cotransporter protein 2 (SGLT2) inhibition on primary open-angle glaucoma (POAG) and explore potential mechanisms. A drug-targeted Mendelian randomization (MR) study was conducted using genetic variation related to SGLT2 inhib...

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Bibliographic Details
Main Authors: Yujin Guo, Jing Zhao, Shuai Hou, Zhiqing Chen
Format: Article
Language:English
Published: Nature Portfolio 2025-04-01
Series:Scientific Reports
Subjects:
Sodium-glucose cotransporter 2 Inhibition
Primary open-angle glaucoma
Mendelian randomization
Drug target
Pharmacological mechanism
Online Access:https://doi.org/10.1038/s41598-025-98997-8
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https://doi.org/10.1038/s41598-025-98997-8

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