CRISPR-Cas9 genetic screens reveal regulation of TMPRSS2 by the Elongin BC-VHL complex

CRISPR-Cas9 genetic screens reveal regulation of TMPRSS2 by the Elongin BC-VHL complex

Abstract The TMPRSS2 cell surface protease is used by a broad range of respiratory viruses to facilitate entry into target cells. Together with ACE2, TMPRSS2 represents a key factor for SARS-CoV-2 infection, as TMPRSS2 mediates cleavage of viral spike protein, enabling direct fusion of the viral env...

Full description

Saved in:
Bibliographic Details
Main Authors: Ildar Gabaev, Alexandra Rowland, Emilija Jovanovic, Christian M. Gawden-Bone, Thomas W. M. Crozier, Ana Teixeira-Silva, Edward J. D. Greenwood, Pehuén Pereyra Gerber, Niek Wit, James A. Nathan, Nicholas J. Matheson, Paul J. Lehner
Format: Article
Language:English
Published: Nature Portfolio 2025-04-01
Series:Scientific Reports
Subjects:
Transmembrane serine proteases
Coronavirus entry factors
CRISPR-Cas9 screen
Colon epithelial cells
Hypoxic regulation of surface proteins
Online Access:https://doi.org/10.1038/s41598-025-95644-0
Tags: Add Tag
No Tags, Be the first to tag this record!

Internet

https://doi.org/10.1038/s41598-025-95644-0

Similar Items