New class of thio/semicarbazide-based benzyloxy derivatives as selective class of monoamine oxidase-B inhibitors

New class of thio/semicarbazide-based benzyloxy derivatives as selective class of monoamine oxidase-B inhibitors

Abstract Sixteen thio/semicarbazide-based benzyloxy derivatives (BT1-BT16) were synthesized and evaluated for their inhibitory activities against monoamine oxidases (MAOs). Most compounds showed better inhibitory activity against MAO-B than against MAO-A. BT1, BT3, and BT5 showed the greatest inhibi...

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Main Authors: Namitha Chandran, Jiseong Lee, Prabitha Prabhakaran, Sunil Kumar, Sachithra Thazhathuveedu Sudevan, Della Grace Thomas Parambi, Tariq G. Alsahli, Manu Pant, Hoon Kim, Bijo Mathew
Format: Article
Language:English
Published: Nature Portfolio 2024-12-01
Series:Scientific Reports
Subjects:
Benzyloxy benzene-based thio/Semicarbazide derivatives
Monoamine oxidase
Kinetics
Reversibility
Molecular dynamics
Online Access:https://doi.org/10.1038/s41598-024-82771-3
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https://doi.org/10.1038/s41598-024-82771-3

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