A novel genome‐wide in vivo screen for metastatic suppressors in human colon cancer identifies the positive WNT‐TCF pathway modulators TMED3 and SOX12

Abstract The progression of tumors to the metastatic state involves the loss of metastatic suppressor functions. Finding these, however, is difficult as in vitro assays do not fully predict metastatic behavior, and the majority of studies have used cloned cell lines, which do not reflect primary tum...

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Bibliographic Details
Main Authors: Arnaud Duquet, Alice Melotti, Sonakshi Mishra, Monica Malerba, Chandan Seth, Arwen Conod, Ariel Ruiz i Altaba
Format: Article
Language:English
Published: Springer Nature 2014-06-01
Series:EMBO Molecular Medicine
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Online Access:https://doi.org/10.15252/emmm.201303799
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