Early plasma ceramide and sphingomyelin levels reflect APOE genotype but not familial Alzheimer's disease gene mutations in female 5xFAD mice, with brain-region specific sphingolipid alterations

Early plasma ceramide and sphingomyelin levels reflect APOE genotype but not familial Alzheimer's disease gene mutations in female 5xFAD mice, with brain-region specific sphingolipid alterations

Pathophysiological changes associated with Alzheimer's disease (AD) begin decades before dementia onset, with age and APOE ε4 genotype as major risk factors [1–4]. Primary risk factors for developing AD include aging and number of copies of the apolipoprotein E (APOE) ε4 allele. Altered sphingo...

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Bibliographic Details
Main Authors: Daan van Kruining, Mario Losen, Jonas Dehairs, Johannes V. Swinnen, Etienne Waelkens, Maarten Honing, Pilar Martinez-Martinez
Format: Article
Language:English
Published: Elsevier 2025-06-01
Series:Neurobiology of Disease
Subjects:
Alzheimer's disease
Sphingolipid metabolism
APOE genotype
Liquid chromatography-tandem mass spectrometry (LC-MS/MS)
Online Access:http://www.sciencedirect.com/science/article/pii/S0969996125001391
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