Integrated analysis of chromatin and transcriptomic profiling of the striatum after cerebral hypoperfusion in mice

Integrated analysis of chromatin and transcriptomic profiling of the striatum after cerebral hypoperfusion in mice

Abstract Background Vascular cognitive impairment (VCI) is a significant contributor to dementia, yet the precise mechanisms underlying the cognitive decline associated with chronic cerebral hypoperfusion (CCH) remain unclear. This study investigated the molecular and epigenetic changes in the stria...

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Main Authors: Shijia Le, Fengyiyang Xu, Zhi Luo, Weihao Shi, Shuangshuang Lu, Zengyu Zhang, Zimin Guo, Wenshi Xu, Mingqi Yang, Tianyi Li, Xu Li, Kun Liang, Lei Zhu
Format: Article
Language:English
Published: BMC 2025-01-01
Series:BMC Genomics
Subjects:
Chronic cerebral hypoperfusion
Bilateral carotid artery stenosis
Striatum
RNA-seq
ATAC-seq
Online Access:https://doi.org/10.1186/s12864-025-11256-y
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https://doi.org/10.1186/s12864-025-11256-y

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