Capsaicin induces ferroptosis via suppression of SLC7A11 activity and upregulation of ACSL4 mediated by AMPK in tongue squamous cell carcinoma

Capsaicin induces ferroptosis via suppression of SLC7A11 activity and upregulation of ACSL4 mediated by AMPK in tongue squamous cell carcinoma

IntroductionThe global incidence of tongue squamous cell carcinoma (TSCC) has been steadily increasing. Our previous studies have demonstrated that capsaicin (CAP) promotes apoptosis and inhibits cell migration, thereby exerting anti-TSCC effects. In this study, we aimed to validate whether CAP indu...

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Bibliographic Details
Main Authors: Qiwei Zhao, Yu Wang, Long Ding, Zhuang Li, Mengyang Wang, Yueqing Huang, Qiushi Cao, Yaqin Sun, Xiaohong Guo
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-05-01
Series:Frontiers in Oncology
Subjects:
capsaicin
ferroptosis
tongue squamous cell carcinoma
AMPK
ACSL4
SLC7A11
Online Access:https://www.frontiersin.org/articles/10.3389/fonc.2025.1532555/full
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https://www.frontiersin.org/articles/10.3389/fonc.2025.1532555/full

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