Microglia exhibit a dynamic response, modulating inducible nitric oxide synthase expression and the production of pro-inflammatory cytokines during experimental cerebral malaria

Microglia exhibit a dynamic response, modulating inducible nitric oxide synthase expression and the production of pro-inflammatory cytokines during experimental cerebral malaria

Microglia play a fundamental role in maintaining central nervous system homeostasis by monitoring brain tissue for physical, structural, and biochemical alterations. Its involvement in the pathogenesis of various neurological disorders is well documented. However, the role of microglia in cerebral m...

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Main Authors: Lucas Freire-Antunes, Uyla Ornellas-Garcia, Marcos Rangel-Ferreira, Mônica Lucas Ribeiro-Almeida, Leonardo José Moura Carvalho, Cláudio Tadeu Daniel-Ribeiro, Flávia Lima Ribeiro-Gomes
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-07-01
Series:Frontiers in Immunology
Subjects:
experimental cerebral malaria
macrophages
malaria
microglia
nitric oxide
IL-1β
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2025.1494418/full
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https://www.frontiersin.org/articles/10.3389/fimmu.2025.1494418/full

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