Potent anti‐tumor response by targeting B cell maturation antigen (BCMA) in a mouse model of multiple myeloma

Potent anti‐tumor response by targeting B cell maturation antigen (BCMA) in a mouse model of multiple myeloma

Multiple myeloma (MM) is an aggressive incurable plasma cell malignancy with a median life expectancy of less than seven years. Antibody‐based therapies have demonstrated substantial clinical benefit for patients with hematological malignancies, particular in B cell Non‐Hodgkin's lymphoma. The...

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Bibliographic Details
Main Authors: Felix Oden, Stephen F. Marino, Janko Brand, Susanne Scheu, Cathleen Kriegel, Daniel Olal, Anna Takvorian, Jörg Westermann, Buket Yilmaz, Michael Hinz, Oliver Daumke, Uta E. Höpken, Gerd Müller, Martin Lipp
Format: Article
Language:English
Published: Wiley 2015-08-01
Series:Molecular Oncology
Subjects:
B cell maturation antigen (BCMA)
Immunotherapy
Multiple myeloma
Monoclonal antibody
Xenograft mouse model
High resolution X-ray structure
Online Access:https://doi.org/10.1016/j.molonc.2015.03.010
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https://doi.org/10.1016/j.molonc.2015.03.010

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