Unraveling the role of NOG gene in hereditary sensory neuropathy type 1F through CRISPR/Cas9-mediated ATL3 knockout

Unraveling the role of NOG gene in hereditary sensory neuropathy type 1F through CRISPR/Cas9-mediated ATL3 knockout

Abstract Background ATL3 pathogenic variations cause hereditary sensory neuropathy type 1F (HSN1F), an autosomal dominant disorder characterized by distal sensory dysfunction manifesting as numbness, tingling, or discomfort. The ATL3 gene encodes the Atl3 protein, which is a member of the ATL family...

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Bibliographic Details
Main Authors: Mahsa Saffar, Mahintaj Dara, Maryam Fazelzadeh Haghighi, Maryam Baneshi, Seyed Mohammad Bagher Tabei
Format: Article
Language:English
Published: SpringerOpen 2025-03-01
Series:Egyptian Journal of Medical Human Genetics
Subjects:
CRISPR/Cas9
ATL3
Hereditary sensory neuropathy
HSN1F
NOG
Online Access:https://doi.org/10.1186/s43042-025-00672-0
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https://doi.org/10.1186/s43042-025-00672-0

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