Designing New Chimeric Proline-Rich Antimicrobial Peptides to Enhance Efficacy Toward the ESKAPE+E: Beyond Sequence Extension

Designing New Chimeric Proline-Rich Antimicrobial Peptides to Enhance Efficacy Toward the ESKAPE+E: Beyond Sequence Extension

Proline-rich antimicrobial peptides (PrAMPs) primarily exert their antimicrobial effects intracellularly, inhibiting protein synthesis. B7-005, a synthetic 16-amino acid PrAMP, has a broader antimicrobial spectrum compared to native counterparts, despite shorter PrAMPs typically exhibiting reduced a...

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Bibliographic Details
Main Authors: Adriana Di Stasi, Luigi de Pascale, Martino Morici, Daniel N. Wilson, Marco Scocchi, Mario Mardirossian
Format: Article
Language:English
Published: MDPI AG 2025-05-01
Series:Biomolecules
Subjects:
drug design
antimicrobial peptide
proline-rich peptide
ESKAPE+E
protein synthesis
antibiotic resistance
Online Access:https://www.mdpi.com/2218-273X/15/6/776
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