The Discovery of Novel Experimental Therapies for Inflammatory Arthritis
Conventional and biologic disease-modifying antirheumatic drugs have revolutionized the medical therapy of inflammatory arthritis. However, it remains unclear as to what can be done to treat immune-mediated chronic inflammation after patients become refractory to these therapies or develop serious s...
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| Format: | Article |
| Language: | English |
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Wiley
2009-01-01
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| Series: | Mediators of Inflammation |
| Online Access: | http://dx.doi.org/10.1155/2009/698769 |
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| author | Charles J. Malemud |
| author_facet | Charles J. Malemud |
| author_sort | Charles J. Malemud |
| collection | DOAJ |
| description | Conventional and biologic disease-modifying antirheumatic drugs have revolutionized the medical therapy of inflammatory arthritis. However, it remains unclear as to what can be done to treat immune-mediated chronic inflammation after patients become refractory to these therapies or develop serious side-effects and/or infections forcing drug withdrawal. Because of these concerns it is imperative that novel targets be continuously identified and experimental strategies designed to test potential arthritis interventions in vitro, but more importantly, in well-validated animal models of inflammatory arthritis. Over the past few years, sphingosine-1-phosphate, interleukin-7 receptor, spleen tyrosine kinase, extracellular signal-regulated kinase, mitogen-activated protein kinase 5/p38 kinase regulated/activated protein kinase, micro-RNAs, tumor necrosis factor-related apoptosis inducing ligand and the polyubiquitin-proteasome pathway were identified as promising novel targets for potential antiarthritis drug development. Indeed several experimental compounds alter the biological activity of these targets and have shown clinical efficacy in animal models of arthritis. A few of them have even entered the first phase of human clinical trials. |
| format | Article |
| id | doaj-art-92d8c551eeb4415fb0d802b378e5981d |
| institution | Kabale University |
| issn | 0962-9351 1466-1861 |
| language | English |
| publishDate | 2009-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Mediators of Inflammation |
| spelling | doaj-art-92d8c551eeb4415fb0d802b378e5981d2025-02-03T06:10:59ZengWileyMediators of Inflammation0962-93511466-18612009-01-01200910.1155/2009/698769698769The Discovery of Novel Experimental Therapies for Inflammatory ArthritisCharles J. Malemud0Division of Rheumatic Diseases, Department of Medicine, University Hospitals Case Medical Center, Case Western Reserve University School of Medicine, Cleveland, OH 44106, USAConventional and biologic disease-modifying antirheumatic drugs have revolutionized the medical therapy of inflammatory arthritis. However, it remains unclear as to what can be done to treat immune-mediated chronic inflammation after patients become refractory to these therapies or develop serious side-effects and/or infections forcing drug withdrawal. Because of these concerns it is imperative that novel targets be continuously identified and experimental strategies designed to test potential arthritis interventions in vitro, but more importantly, in well-validated animal models of inflammatory arthritis. Over the past few years, sphingosine-1-phosphate, interleukin-7 receptor, spleen tyrosine kinase, extracellular signal-regulated kinase, mitogen-activated protein kinase 5/p38 kinase regulated/activated protein kinase, micro-RNAs, tumor necrosis factor-related apoptosis inducing ligand and the polyubiquitin-proteasome pathway were identified as promising novel targets for potential antiarthritis drug development. Indeed several experimental compounds alter the biological activity of these targets and have shown clinical efficacy in animal models of arthritis. A few of them have even entered the first phase of human clinical trials.http://dx.doi.org/10.1155/2009/698769 |
| spellingShingle | Charles J. Malemud The Discovery of Novel Experimental Therapies for Inflammatory Arthritis Mediators of Inflammation |
| title | The Discovery of Novel Experimental Therapies for Inflammatory Arthritis |
| title_full | The Discovery of Novel Experimental Therapies for Inflammatory Arthritis |
| title_fullStr | The Discovery of Novel Experimental Therapies for Inflammatory Arthritis |
| title_full_unstemmed | The Discovery of Novel Experimental Therapies for Inflammatory Arthritis |
| title_short | The Discovery of Novel Experimental Therapies for Inflammatory Arthritis |
| title_sort | discovery of novel experimental therapies for inflammatory arthritis |
| url | http://dx.doi.org/10.1155/2009/698769 |
| work_keys_str_mv | AT charlesjmalemud thediscoveryofnovelexperimentaltherapiesforinflammatoryarthritis AT charlesjmalemud discoveryofnovelexperimentaltherapiesforinflammatoryarthritis |