Relaxing parametric assumptions for non-linear Mendelian randomization using a doubly-ranked stratification method.
Non-linear Mendelian randomization is an extension to standard Mendelian randomization to explore the shape of the causal relationship between an exposure and outcome using an instrumental variable. A stratification approach to non-linear Mendelian randomization divides the population into strata an...
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| Main Authors: | Haodong Tian, Amy M Mason, Cunhao Liu, Stephen Burgess |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Public Library of Science (PLoS)
2023-06-01
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| Series: | PLoS Genetics |
| Online Access: | https://journals.plos.org/plosgenetics/article/file?id=10.1371/journal.pgen.1010823&type=printable |
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