Relaxing parametric assumptions for non-linear Mendelian randomization using a doubly-ranked stratification method.

Non-linear Mendelian randomization is an extension to standard Mendelian randomization to explore the shape of the causal relationship between an exposure and outcome using an instrumental variable. A stratification approach to non-linear Mendelian randomization divides the population into strata an...

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Bibliographic Details
Main Authors: Haodong Tian, Amy M Mason, Cunhao Liu, Stephen Burgess
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2023-06-01
Series:PLoS Genetics
Online Access:https://journals.plos.org/plosgenetics/article/file?id=10.1371/journal.pgen.1010823&type=printable
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