PHD3-VHL axis controls HIV-2 infection through oxygen-dependent hydroxylation and degradation of Vpx.

PHD3-VHL axis controls HIV-2 infection through oxygen-dependent hydroxylation and degradation of Vpx.

HIV-2 viral protein X (Vpx) plays a pivotal role in antagonizing the host restriction factors, including SAMHD1 and components of the HUSH complex, to facilitate viral replication. However, the regulatory mechanisms controlling Vpx stability remain unclear. In this study, we identify the von Hippel-...

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Main Authors: Kei Miyakawa, Kiho Tanaka, Yoko Ino, Yayoi Kimura, Taichi Kameya, Fuminori Mizukoshi, Mayuko Nishi, Masaru Yokoyama, Jun Nakabayashi, Masako Nomaguchi, Hironori Sato, Hirokazu Kimura, Hirofumi Akari, Tomoyuki Miura, Akinori Takaoka, Hideki Hasegawa, Tetsuro Matano, Yoji Andrew Minamishima, Akihide Ryo
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2025-06-01
Series:PLoS Pathogens
Online Access:https://doi.org/10.1371/journal.ppat.1013241
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https://doi.org/10.1371/journal.ppat.1013241

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