Using of transporter proteins to improve the uptake efficiency of hydrophobic compounds by Escherichia coli: a coordinated synthesis of START protein and P450scc system proteins to enhance cholesterol biotransformation

Using of transporter proteins to improve the uptake efficiency of hydrophobic compounds by Escherichia coli: a coordinated synthesis of START protein and P450scc system proteins to enhance cholesterol biotransformation

Abstract Synthesis of steroid drugs is possible through biotechnological methods, however, the low efficiency of transporting steroid substrates across microbial membranes is the challenge in using microorganisms for their production. STARD1 and STARD3 proteins (members of the START domain family) w...

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Main Authors: Sofia V. Zamalutdinova, Ludmila V. Isaeva, Yaroslav V. Faletrov, Nikolay N. Eroshchenko, Alexey N. Kirushin, Vadim N. Tashlitsky, Mikhail A. Rubtsov, Ludmila A. Novikova
Format: Article
Language:English
Published: SpringerOpen 2025-07-01
Series:Bioresources and Bioprocessing
Online Access:https://doi.org/10.1186/s40643-025-00909-1
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https://doi.org/10.1186/s40643-025-00909-1

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