Factor-H-related protein 1 (FHR1), a promotor of para-inflammation in age-related macular degeneration

Factor-H-related protein 1 (FHR1), a promotor of para-inflammation in age-related macular degeneration

Abstract Age-related macular degeneration (AMD), a multifactorial type of retinal degeneration represents the most common cause for blindness in elderly. Polymorphisms in complement factor-H increase, while absence of factor-H-related protein-1 (FHR1) decreases the AMD risk, currently explained by t...

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Main Authors: Andjela Sekulic, Sarah M. Herr, Kelly Mulfaul, Inga-Marie Pompös, Silvia Winkler, Carola Dietrich, Benedikt Obermayer, Robert F. Mullins, Thomas Conrad, Peter F. Zipfel, Florian Sennlaub, Christine Skerka, Olaf Strauß
Format: Article
Language:English
Published: BMC 2025-07-01
Series:Journal of Neuroinflammation
Subjects:
Age-related macular degeneration
Retinal pigment epithelium
Complement system
Inflammation
Online Access:https://doi.org/10.1186/s12974-025-03499-z
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https://doi.org/10.1186/s12974-025-03499-z

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