ECM formation and degradation during fibrosis, repair, and regeneration

ECM formation and degradation during fibrosis, repair, and regeneration

Abstract Imperfect attempts at organ repair after repeated injury result in aberrant formation of extracellular matrix (ECM) and loss of tissue structure. This abnormal ECM goes from being a consequence of cellular dysregulation to become the backbone of a persistently fibrotic cell niche that compr...

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Main Authors: Alejandro E. Mayorca-Guiliani, Diana Julie Leeming, Kim Henriksen, Joachim Høg Mortensen, Signe Holm Nielsen, Quentin M. Anstee, Arun J. Sanyal, Morten A. Karsdal, Detlef Schuppan
Format: Article
Language:English
Published: Nature Portfolio 2025-06-01
Series:npj Metabolic Health and Disease
Online Access:https://doi.org/10.1038/s44324-025-00063-4
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https://doi.org/10.1038/s44324-025-00063-4

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