Identification of a BACH1 lung cancer signature: A novel tool for understanding BACH1 biology and identifying new inhibitors

Identification of a BACH1 lung cancer signature: A novel tool for understanding BACH1 biology and identifying new inhibitors

BACH1 is a transcriptional repressor that regulates oxidative stress and inflammatory responses and has emerged as a promising therapeutic target in cancer and other diseases. In lung cancer, BACH1 overexpression is linked to poor prognosis and metastasis, yet a consistent transcriptional signature...

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Bibliographic Details
Main Authors: Donika Klenja-Skudrinja, Kevin X. Ali, David Walker, Maureen Higgins, Angana AH. Patel, Dorota Raj, Anna Creelman, Charlotte McDowall, Conor Taylor, Tomasz Wenta, Erik Larsson, Clotilde Wiel, Volkan I. Sayin, Laureano de la Vega
Format: Article
Language:English
Published: Elsevier 2025-09-01
Series:Redox Biology
Subjects:
BACH1
Lung cancer
Gene signature
Metastasis
Online Access:http://www.sciencedirect.com/science/article/pii/S2213231725003027
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