The activation of cGAS-STING pathway offers novel therapeutic opportunities in cancers

The activation of cGAS-STING pathway offers novel therapeutic opportunities in cancers

The cyclic GMP-AMP synthase (cGAS)/stimulator of interferon genes (STING) pathway are crucial elements of the type I interferon (type I IFN) response. cGAS senses both exogenous and endogenous DNA within cells, labeling cGAS-STING as a pivotal anti-tumor immunity mechanism, autoimmunity, sterile inf...

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Bibliographic Details
Main Authors: Yumin Wang, Yonglin Zhu, Yuwei Cao, Yulin Li, Zhe Zhang, Joshua S. Fleishman, Sihang Cheng, Jichao Chen, Mingchao Ding
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-06-01
Series:Frontiers in Immunology
Subjects:
CGAS
STING
agonist
cancers contents
small-molecule compounds
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2025.1579832/full
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https://www.frontiersin.org/articles/10.3389/fimmu.2025.1579832/full

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