Integrated chemical analysis, metabolic profiling, network pharmacology, molecular docking and toxicity prediction to reveal the active ingredients and their safety of raw and prepared rhubarbs in the treatment of gastric ulcers

Integrated chemical analysis, metabolic profiling, network pharmacology, molecular docking and toxicity prediction to reveal the active ingredients and their safety of raw and prepared rhubarbs in the treatment of gastric ulcers

BackgroundRhubarb, containing raw rhubarb (RR) and two processed products (steamed rhubarb, SR; carbonized rhubarb, CR), is commonly used in high-doses for the treatment of peptic ulcer, especially gastric ulcer (GU). However, their active ingredients, therapeutic targets, and potential mechanism re...

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Bibliographic Details
Main Authors: Chenxi Wang, Xin Zhao, Jingjing Jiang, Mengqi Jia, Wenqing Shi, Zhenghua Wu, Shiyu Feng, Guorong Fan, Yuefen Lou
Format: Article
Language:English
Published: Frontiers Media S.A. 2024-11-01
Series:Frontiers in Pharmacology
Subjects:
raw and prepared rhubarbs
chemical analysis in vitro
metabolite profiling in vivo
network pharmacology
molecular docking
toxicity prediction
Online Access:https://www.frontiersin.org/articles/10.3389/fphar.2024.1481091/full
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https://www.frontiersin.org/articles/10.3389/fphar.2024.1481091/full

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