Enhanced breast cancer cell targeting: RGD integrin ligand potentiates RWQWRWQWR’s cytotoxicity and inhibits migration

Enhanced breast cancer cell targeting: RGD integrin ligand potentiates RWQWRWQWR’s cytotoxicity and inhibits migration

Aim: Evaluate the selective cytotoxic effect of the palindromic sequence RWQWRWQWR and its analogues obtained by replacement of L-amino acids by D-amino acids or the functionalization by adding the RGD (integrin ligand motif) to the peptide. Methods: Peptides were obtained by SPPS, characterized by...

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Main Authors: Andrea Barragán-Cárdenas, Daniel Castellar-Almonacid, Yerly Vargas-Casanova, Claudia Parra-Giraldo, Adriana Umaña-Pérez, Joel López-Meza, Zuly Rivera-Monroy, Javier García-Castañeda
Format: Article
Language:English
Published: Open Exploration 2024-07-01
Series:Exploration of Drug Science
Subjects:
breast cancer
anticancer peptides
apoptosis
migration
Online Access:https://www.explorationpub.com/uploads/Article/A100852/100852.pdf
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https://www.explorationpub.com/uploads/Article/A100852/100852.pdf

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