Presence of tumor DNA in aqueous humor is correlated with high risk uveal melanoma

Presence of tumor DNA in aqueous humor is correlated with high risk uveal melanoma

Abstract Metastatic risk stratification is critical for uveal melanoma (UM) management, as approximately up to half of patients develop metastatic disease. Current prognostication for patients undergoing eye-preserving therapies relies on tumor staging and molecular analysis of tumor tissue obtained...

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Main Authors: Nicole Barwinski, Mael Lever, Philipp Rating, Leyla Jabbarli, Miltiadis Fiorentzis, Nikolaos E. Bechrakis, Dietmar R. Lohmann, Michael Zeschnigk, Claudia H. D. Le Guin
Format: Article
Language:English
Published: Nature Portfolio 2025-06-01
Series:Scientific Reports
Subjects:
CfDNA
Liquid biopsy
Prognostic testing
Uveal melanoma
Ocular liquids
Aqueous humor
Online Access:https://doi.org/10.1038/s41598-025-03915-7
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https://doi.org/10.1038/s41598-025-03915-7

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