Assessment of drug permeability using a small airway microphysiological system

Assessment of drug permeability using a small airway microphysiological system

BackgroundThere is a need to reliably predict the permeability of inhaled compounds during the development of new and generic drugs. A small airway microphysiological system (MPS) that can recapitulate the pulmonary air-liquid interface (ALI) with primary epithelial and vascular endothelial cell lay...

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Main Authors: Robert M. Geiger, Shekh M. Rahman, Md Shadiqur Rashid Roni, Catherine Sullenberger, Sabyasachy Mistry, Katherine Shea, Isra Tariq, Omnia A. Ismaiel, Murali K. Matta, Paula L. Hyland, Sasha Berdichevski, Alexandre J. S. Ribeiro, Ksenia Blinova, Wenlei Jiang, Ross L. Walenga, Bryan Newman, Donna A. Volpe, Kevin A. Ford
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-07-01
Series:Frontiers in Pharmacology
Subjects:
microphysiological system
permeability
regulatory science
small airway
inhaled drugs
Online Access:https://www.frontiersin.org/articles/10.3389/fphar.2025.1621775/full
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https://www.frontiersin.org/articles/10.3389/fphar.2025.1621775/full

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