Synephrine Analogues as Glucocorticoid Receptor Agonists

Synephrine Analogues as Glucocorticoid Receptor Agonists

This work carried out the synthesis of several new synephrine analogues by universal method. Some of the synthesized compounds showed cytotoxicity on myeloid leukaemia cells K562 and lymphoma cell line Granta-519. Molecular docking using the glucocorticoid receptor (GR) model (PDB identifier 1P93) w...

Full description

Saved in:
Bibliographic Details
Main Authors: Eugenia Oleynik, Ekaterina Mikhina, Diana Grigoreva, Varvara Maksimova, Lyubov Grebenkina, Andrey Valerevich Matveev, Ekaterina Zhidkova, Ekaterina Lesovaya, Marianna Yakubovskaya
Format: Article
Language:English
Published: MDPI AG 2023-11-01
Series:Chemistry Proceedings
Subjects:
glucocorticoid receptor
synephrine analogues
chronic myelogenous leukaemia
mantle cell lymphoma
Online Access:https://www.mdpi.com/2673-4583/14/1/58
Tags: Add Tag
No Tags, Be the first to tag this record!

Internet

https://www.mdpi.com/2673-4583/14/1/58

Similar Items