Hypoxia-inducible factor 2α mediates nonesterified fatty acids and hypoxia-induced lipid accumulation in bovine hepatocytes

Hypoxia-inducible factor 2α mediates nonesterified fatty acids and hypoxia-induced lipid accumulation in bovine hepatocytes

ABSTRACT: Ketosis is a metabolic disorder frequently occurring in the perinatal period, characterized by elevated circulating concentrations of nonesterified fatty acids (NEFA) due to negative energy balance, resulting in fatty liver in dairy cows. However, the mechanism of hepatic steatosis induced...

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Main Authors: Fanrong Kong, Lin Lei, Lin Cai, Jinxia Li, Chenchen Zhao, Menglin Liu, Dandan Qi, Jie Gao, Enzhu Li, Wenwen Gao, Xiliang Du, Yuxiang Song, Guowen Liu, Xinwei Li
Format: Article
Language:English
Published: Elsevier 2025-04-01
Series:Journal of Dairy Science
Subjects:
dairy cows
ketosis
fatty liver
hypoxia
HIF-2α/ATF4
Online Access:http://www.sciencedirect.com/science/article/pii/S0022030225000475
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