Release of prostaglandin D2 by murine mast cells: importance of metabolite formation for antiproliferative activity

Release of prostaglandin D2 by murine mast cells: importance of metabolite formation for antiproliferative activity

Prostaglandin (PG) D2 , PGJ2 and Δ12 -PGJ2 are antiproliferative eicosanoids. We investigated the production of PGD2 by murine bone marrow-derived mast cells (BMMC) taking into consideration metabolism of PGD2 to PGD2 and Δ12-PGJ2. PG-metabolites were quantified by high performance liquid chromatogr...

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Bibliographic Details
Main Authors: C. Haberl, L. Hültner, A. Flügel, M. Falk, S. Geuenich, W. Wilmanns, C. Denzlinger
Format: Article
Language:English
Published: Wiley 1998-01-01
Series:Mediators of Inflammation
Subjects:
Prostaglandin D2
Prostaglandin J2
Δ12-Prostaglandin J2
Cyclopentenone
Anti-Proliferative activity
Mast cell.
Online Access:http://dx.doi.org/10.1080/09629359891216
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