Plexiform Schwannoma of the Tongue in a Pediatric Patient with Neurofibromatosis Type 2: A Case Report and Review of Literature
Introduction. Plexiform schwannoma is a rare variant of schwannoma that accounts for only 5% of all schwannomas. Herein, we present a rare case of plexiform schwannoma of the tongue in a pediatric patient with neurofibromatosis type 2 (NF2). Case Presentation. A 13-year-old female presented with a g...
Saved in:
| Main Authors: | , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Wiley
2018-01-01
|
| Series: | Case Reports in Pathology |
| Online Access: | http://dx.doi.org/10.1155/2018/9814591 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1832557115607089152 |
|---|---|
| author | Samir M. Amer Aijan Ukudeyeva Harold S. Pine Gerald A. Campbell Cecilia G. Clement |
| author_facet | Samir M. Amer Aijan Ukudeyeva Harold S. Pine Gerald A. Campbell Cecilia G. Clement |
| author_sort | Samir M. Amer |
| collection | DOAJ |
| description | Introduction. Plexiform schwannoma is a rare variant of schwannoma that accounts for only 5% of all schwannomas. Herein, we present a rare case of plexiform schwannoma of the tongue in a pediatric patient with neurofibromatosis type 2 (NF2). Case Presentation. A 13-year-old female presented with a growing left-sided tongue mass. The patient has a past medical history of NF2. The tongue mass was excised and histopathological examination revealed a spindle cell tumor with multinodular growth pattern, with Verocay bodies' formation. Tumor cells were strongly positive for S-100 protein and negative for smooth muscle actin (SMA), and EMA highlighted perineural fibroblasts surrounding tumor nodules. These findings were diagnostic of plexiform schwannoma. Conclusion. Plexiform schwannoma of the tongue is an extremely rare tumor seen in patients with NF2. Clinical examination and histopathological evaluation are important for diagnosis of plexiform schwannoma. |
| format | Article |
| id | doaj-art-9215f8e8ccc140c4904ec74cde0a88ee |
| institution | Kabale University |
| issn | 2090-6781 2090-679X |
| language | English |
| publishDate | 2018-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Case Reports in Pathology |
| spelling | doaj-art-9215f8e8ccc140c4904ec74cde0a88ee2025-02-03T05:43:41ZengWileyCase Reports in Pathology2090-67812090-679X2018-01-01201810.1155/2018/98145919814591Plexiform Schwannoma of the Tongue in a Pediatric Patient with Neurofibromatosis Type 2: A Case Report and Review of LiteratureSamir M. Amer0Aijan Ukudeyeva1Harold S. Pine2Gerald A. Campbell3Cecilia G. Clement4Department of Pathology, The University of Texas Medical Branch, Galveston, TX 77555, USADepartment of Pathology, The University of Texas Medical Branch, Galveston, TX 77555, USADepartment of Otolaryngology, The University of Texas Medical Branch, Galveston, TX 77555, USADepartment of Pathology, The University of Texas Medical Branch, Galveston, TX 77555, USADepartment of Pathology, The University of Texas Medical Branch, Galveston, TX 77555, USAIntroduction. Plexiform schwannoma is a rare variant of schwannoma that accounts for only 5% of all schwannomas. Herein, we present a rare case of plexiform schwannoma of the tongue in a pediatric patient with neurofibromatosis type 2 (NF2). Case Presentation. A 13-year-old female presented with a growing left-sided tongue mass. The patient has a past medical history of NF2. The tongue mass was excised and histopathological examination revealed a spindle cell tumor with multinodular growth pattern, with Verocay bodies' formation. Tumor cells were strongly positive for S-100 protein and negative for smooth muscle actin (SMA), and EMA highlighted perineural fibroblasts surrounding tumor nodules. These findings were diagnostic of plexiform schwannoma. Conclusion. Plexiform schwannoma of the tongue is an extremely rare tumor seen in patients with NF2. Clinical examination and histopathological evaluation are important for diagnosis of plexiform schwannoma.http://dx.doi.org/10.1155/2018/9814591 |
| spellingShingle | Samir M. Amer Aijan Ukudeyeva Harold S. Pine Gerald A. Campbell Cecilia G. Clement Plexiform Schwannoma of the Tongue in a Pediatric Patient with Neurofibromatosis Type 2: A Case Report and Review of Literature Case Reports in Pathology |
| title | Plexiform Schwannoma of the Tongue in a Pediatric Patient with Neurofibromatosis Type 2: A Case Report and Review of Literature |
| title_full | Plexiform Schwannoma of the Tongue in a Pediatric Patient with Neurofibromatosis Type 2: A Case Report and Review of Literature |
| title_fullStr | Plexiform Schwannoma of the Tongue in a Pediatric Patient with Neurofibromatosis Type 2: A Case Report and Review of Literature |
| title_full_unstemmed | Plexiform Schwannoma of the Tongue in a Pediatric Patient with Neurofibromatosis Type 2: A Case Report and Review of Literature |
| title_short | Plexiform Schwannoma of the Tongue in a Pediatric Patient with Neurofibromatosis Type 2: A Case Report and Review of Literature |
| title_sort | plexiform schwannoma of the tongue in a pediatric patient with neurofibromatosis type 2 a case report and review of literature |
| url | http://dx.doi.org/10.1155/2018/9814591 |
| work_keys_str_mv | AT samirmamer plexiformschwannomaofthetongueinapediatricpatientwithneurofibromatosistype2acasereportandreviewofliterature AT aijanukudeyeva plexiformschwannomaofthetongueinapediatricpatientwithneurofibromatosistype2acasereportandreviewofliterature AT haroldspine plexiformschwannomaofthetongueinapediatricpatientwithneurofibromatosistype2acasereportandreviewofliterature AT geraldacampbell plexiformschwannomaofthetongueinapediatricpatientwithneurofibromatosistype2acasereportandreviewofliterature AT ceciliagclement plexiformschwannomaofthetongueinapediatricpatientwithneurofibromatosistype2acasereportandreviewofliterature |