Novel modulators of p53-signaling encoded by unknown genes of emerging viruses.

Novel modulators of p53-signaling encoded by unknown genes of emerging viruses.

The p53 transcription factor plays a key role both in cancer and in the cell-intrinsic response to infections. The ORFEOME project hypothesized that novel p53-virus interactions reside in hitherto uncharacterized, unknown, or hypothetical open reading frames (orfs) of human viruses. Hence, 172 orfs...

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Main Authors: Dina Alzhanova, Kathleen Corcoran, Aubrey G Bailey, Kristin Long, Sharon Taft-Benz, Rachel L Graham, Grant S Broussard, Mark Heise, Gabriele Neumann, Peter Halfmann, Yoshihiro Kawaoka, Ralph S Baric, Blossom Damania, Dirk P Dittmer
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2021-01-01
Series:PLoS Pathogens
Online Access:https://journals.plos.org/plospathogens/article/file?id=10.1371/journal.ppat.1009033&type=printable
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https://journals.plos.org/plospathogens/article/file?id=10.1371/journal.ppat.1009033&type=printable

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