DNA repair and the contribution to chemotherapy resistance

Abstract The DNA damage response comprises a set of imperfect pathways that maintain cell survival following exposure to DNA damaging agents. Cancers frequently exhibit DNA repair pathway alterations that contribute to their intrinsic genome instability. This, in part, facilitates a therapeutic wind...

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Bibliographic Details
Main Authors: Ksenija Nesic, Phoebe Parker, Elizabeth M. Swisher, John J. Krais
Format: Article
Language:English
Published: BMC 2025-05-01
Series:Genome Medicine
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Online Access:https://doi.org/10.1186/s13073-025-01488-8
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