3D-printed manganese dioxide incorporated scaffold promotes osteogenic-angiogenic coupling for refractory bone defect by remodeling osteo-regenerative microenvironment

3D-printed manganese dioxide incorporated scaffold promotes osteogenic-angiogenic coupling for refractory bone defect by remodeling osteo-regenerative microenvironment

The treatment of refractory bone defects is a major clinical challenge, especially in steroid-associated osteonecrosis (SAON), which is characterized by insufficient osteogenesis and angiogenesis. Herin, a microenvironment responsiveness scaffold composed of poly-L-lactide (PLLA), and manganese diox...

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Bibliographic Details
Main Authors: Yipei Yang, Zhenyu Yao, Yuanyi Sun, Yangyi Nie, Yuanchi Zhang, Ziyue Li, Zhiheng Luo, Wenjing Zhang, Xiao Wang, Yuhan Du, Wei Zhang, Ling Qin, Hongxun Sang, Yuxiao Lai
Format: Article
Language:English
Published: KeAi Communications Co., Ltd. 2025-02-01
Series:Bioactive Materials
Subjects:
Osteogenic-angiogenic coupling
Steroid-associated osteonecrosis
Manganese dioxide
Refractory bone defect
Online Access:http://www.sciencedirect.com/science/article/pii/S2452199X2400464X
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