Novel cancer stem cell-targeted retinoid ZSH-512 impedes colorectal cancer progress via KDM3A-mediated epigenetic reprogramming

Novel cancer stem cell-targeted retinoid ZSH-512 impedes colorectal cancer progress via KDM3A-mediated epigenetic reprogramming

Advanced colorectal cancer (CRC) exhibits weak responses to multiple therapies, primarily due to the presence of cancer stem cells (CSCs), which drive high recurrence rates, metastasis, and drug resistance. We have previously systematically conducted CSC-targeted compound discovery and evaluation st...

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Bibliographic Details
Main Authors: Suyao Li, Wenrui Zhao, Quanlin An, Lei Wang, Mengxuan Zhu, Junjie Ni, Xuan Huang, Yudong Jiang, Min Li, Jiayun Hou, Yiyi Yu, Shan Yu, Lai Wei, Heng Jiao, Tianshu Liu, Xin Cao
Format: Article
Language:English
Published: Elsevier 2025-04-01
Series:The Innovation
Subjects:
ZSH-512
colorectal cancer
KDM3A
cancer stem cell
tumor-repopulating cell
retinoid
Online Access:http://www.sciencedirect.com/science/article/pii/S2666675825000347
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