Single-Nucleus RNA Sequencing Reveals the Spatiotemporal Dynamics of Disease-Associated Microglia in Amyotrophic Lateral Sclerosis

Disease-associated microglia (DAM) are observed in neurodegenerative diseases, demyelinating disorders, and aging. However, the spatiotemporal dynamics and evolutionary trajectory of DAM during the progression of amyotrophic lateral sclerosis (ALS) remain unclear. Using a mouse model of ALS that exp...

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Main Authors: Lu-Xi Chen, Mei-Di Zhang, Hai-Feng Xu, Hai-Qin Ye, Dian-Fu Chen, Pei-Shan Wang, Zhi-Wei Bao, Sheng-Mei Zou, Yong-Ting Lv, Zhi-Ying Wu, Hong-Fu Li
Format: Article
Language:English
Published: American Association for the Advancement of Science (AAAS) 2024-01-01
Series:Research
Online Access:https://spj.science.org/doi/10.34133/research.0548
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