Exploring of N-phthalimide-linked 1,2,3-triazole analogues with promising ­anti-SARS-CoV-2 activity: synthesis, biological screening, and molecular modelling studies

Exploring of N-phthalimide-linked 1,2,3-triazole analogues with promising ­anti-SARS-CoV-2 activity: synthesis, biological screening, and molecular modelling studies

In this study, a library of phthalimide Schiff base linked to 1,4-disubstituted-1,2,3-triazoles was designed, synthesised, and characterised by different spectral analyses. All analogues have been introduced for in vitro assay of their antiviral activity against COVID-19 virus using Vero cell as inc...

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Bibliographic Details
Main Authors: Ateyatallah Aljuhani, Mosa Alsehli, Mohamed A. Seleem, Shaya Y. Alraqa, Hany E. A. Ahmed, Nadjet Rezki, Mohamed R. Aouad
Format: Article
Language:English
Published: Taylor & Francis Group 2024-12-01
Series:Journal of Enzyme Inhibition and Medicinal Chemistry
Subjects:
123-Triazole
phtalamide
Schiff bases
COVID-19
molecular docking
Online Access:https://www.tandfonline.com/doi/10.1080/14756366.2024.2351861
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https://www.tandfonline.com/doi/10.1080/14756366.2024.2351861

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